(4) Potential mechanisms may involve reduction of NF-B and MAP kinase signaling, and interactions with vasodilators like nitric oxide (NO), thereby possibly lowering pro-inflammatory cytokine output
One naturally occurring peptide, Epithalamin, produced in the pineal gland, has been linked to increased melatonin production, enhanced immune and anti-carcinogenic functions in rodent models, and restoration of reproductive function in aged rodents
Students designing follow-on experiments often start with these signaling maps to frame their hypotheses
Snell, G
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